Research Project Database
Code: EMIDA17
Title: CamChain - Campylobacter in chicken production: survival, virulence and control
Country: United Kingdom
Finland
Denmark
Italy
France
Austria
Lithuania
Funding Organisation: Biotechnology and Biological Science Research Council (BBSRC)
Department for the Environment, Food and Rural Affairs (Defra)
French National Research Agency (ANR)
The Ministry of Agriculture of Lithuania (MAL)
The Ministry of Food, Agriculture and Fisheries of Denmark
Finnish Ministry of Agriculture and Forestry
Austrian Federal Ministry of Health
Italian Ministry of Health Department for Veterinary Public Health, Nutrition and Food Safety
Animal Group: Chickens
Pathogen: Campylobacter spp.
Disease: Campylobacteriosis
Category: Epidemiology, Risk and Decision Support > Active surveillance
Epidemiology, Risk and Decision Support > Development, refinement, and evaluation of control strategies
Epidemiology, Risk and Decision Support > Generic/Fundamental epidemiology and modelling
Epidemiology, Risk and Decision Support > Modelling disease dynamics in animal populations
Epidemiology, Risk and Decision Support > Risk analysis of pathogen introduction, persistence or extension
Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Bacteriology
Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Host-Pathogen interactions (including immunomodulation and immune evasion)
Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Molecular epidemiology
Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Transmission Experiments
Research Organisation: University of Cambridge
National Veterinary Institute (DTU Vet)
University of Liverpool
University of Helsinki
Austrian Agency for Health and Food Safety (AGES)
University of Veterinary Medicine Vienna
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise
Lithuanian University of Health Sciences, Veterinary Academy
French Agency for Food, Environmental and Occupational Health & Safety (ANSES)
Number of Research Staff (FTE):  
Principal Investigator (PI): Prof. Tom Humphrey, Liverpool University
Cost (Euros): 3580384
End Date (dd/mm/yyyy): 31-03-2015
Duration (months): 36
Link:  
Project objectives and deliverables with estimated delivery dates for each deliverable (if possible): The project addresses EMIDA programme C1: Control strategies for Campylobacter in poultry. Our aim is to develop science-led interventions to reduce consumer exposure to Campylobacter. The project will have partners in the EU poultry industry and other stakeholders. We will identify intervention strategies on-farm and during processing to control contamination and will provide knowledge on population, transmission, and infection biology of Campylobacter. The consortium comprises groups in the UK, Austria, Denmark, Finland, France, Italy, Lithuania, Thailand and Viet Nam. The Thai and Vietnamese governments will fund their work directly and through related food safety poultry projects. Our studies will address:; ? Molecular epidemiology and surveillance tools; ? Survival and propagation in the chicken production chain from ?farm to fork?; ? Virulence mechanisms and host-pathogen interactions; ? Modelling transmission within flocks and risk progression along the production chain; ? Intervention based on enhanced biosecurity and improved host resistance; Our focus is on housed broilers and we will:; ? Investigate the Campylobacter pathway from environmental source, to colonisation and within-flock spread, to processing.; ? Examine on-farm and within-processing interventions in combination and the potential protective effects of pre- and probiotics.; ? Quantify the impacts of management, climatic factors and bird health events on the Campylobacter pathway. ? Examine Campylobacter population structures in different broiler systems and the factors that determine them; ? Analyse the environmental sources of Campylobacter on farms, quantifying changes in numbers and populations in relation to climate and season in different EU states and in SE Asia.; ? Determine the role of protozoal/algal 'hosts' as natural 'reservoirs' of Campylobacter and if insects are important sources of these bacteria.; ? Follow broilers from farm to consumers and determine how processing and subsequent storage affect Campylobacter numbers and population structure.; ? Examine survival of common Campylobacter types in laboratory models and determine if exposure to environment affects virulence and the progression along the pathway.; ? Use cutting edge molecular techniques to determine mechanisms of C. jejuni that allow it to persist in the environment and in the chicken gut.; ? Investigate sensitivity and specificity of boot socks as potential surveillance tools; ? Integrate the results into state of the art modelling and risk assessment tools which will be used to determine risk and the impact of intervention. This will inform poultry producers and other stakeholders .
Draft: DRAFT
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