Research Project Database
Code: EMIDA18
Title: CARES - Coping with anthelmintic resistance in ruminants
Country: Denmark
Funding Organisation: French National Research Agency (ANR)
The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning
Department of Agriculture, Fisheries and Food (DAFF)
The Ministry of Food, Agriculture and Fisheries of Denmark
Greek Ministry of Education
Animal Group: Cattle
Pathogen: Nematodes
Disease: Nematode infections
Research Organisation: National Veterinary Institute (DTU Vet)
University of Copenhagen
Swedish University of Agricultural Sciences (SLU)
INRA - Institut National de la Recherche Agronomique
NAGREF - National Agricultural Research Foundation
Central Veterinary Research Laboratory
McGill University
INRA Antilles-Guyane
Number of Research Staff (FTE):  
Principal Investigator (PI): Prof. Stig Milan Thamsborg, University of Copenhagen
Cost (Euros): 1305692
End Date (dd/mm/yyyy): 31-03-2015
Duration (months): 36
Project objectives and deliverables with estimated delivery dates for each deliverable (if possible): Infections with gastrointestinal nematodes (GIN) are a major threat to ruminant health, welfare and production and thus to the viability of the ruminant livestock industries in the EU and worldwide. Anthelmintic resistance (AR) is the single-most important problem facing EU ruminant farmers today in relation to sustainable GIN control. AR is a constantly expanding process, from small ruminants to cattle; from the first commercialised anthelmintics (AH) to the modern ones and from single drug AR to multiresistant cases. Therefore, Coping with Anthelmintic RESistance (CARES) is pivotal to all existing and up-coming means of control.

CARES believes that within a foreseeable future the most sustainable strategy is a combination of
approaches, namely i) early detection of AR, ii) use of bioactive crops with documented AH properties, iii) improved farm management, feeding and selective use of AH drugs. This applied approach needs support by basic research and better understanding of mechanisms of development and reversion of AR.

The project CARES will address these key issues through 3 complementary aims:

- Improving the detection of AR in GINs (WP1)
The aims are to improve the usability and reliability of current phenotypic tools but also to develop and validate molecular markers for the early detection of AR development and spread, particularly against macrocyclic lactones (ML)
- Assessing the role of plant resources to replace (WP2) or improve (WP3) the activity of synthetic AHs against AR GINs
The aims are to test the hypothesis of either direct AH effects of plant secondary metabolites (PSMs) against resistant (and susceptible) GINs (WP2); or indirect effects because some PSMs can potentially act as reversing agent for AR against ML (WP3). In vitro studies will provide basic data on the efficacy of active plants against AR GINs, either directly or in combination with AH drugs. In vivo studies will
provide results for future exploitation of bioactive plants on-farm.
- Exploring options for on-farm intervention (WP4)
Integration is a key word for the sustainable control of GINs. The aims are to explore how combinations of solutions, adapting herd management systems, the use of natural AH or a selective use of AH can contribute to effective GIN control and slow down the spread of AR.

The consortium is built on cross-linking criteria to address the objectives. Indeed, CARES brings together 8 partners from 5 EU countries plus a world leading research partner from Canada. These partners:
- belong to major national institutions
- are internationally recognised within the fields addressed, e.g. mechanisms of AR, alternative medication by AH plants, herd management
- have expertise to address basic and applied research questions coping with AR
-have had long-term collaboration, e.g. other EU-projects
- cover a wide range of ecological conditions from the arctic to tropics
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