Research Project Database
Code: EMIDA25
Title: MOLTRAQ – Molecular tracing of viral pathogens in aquaculture
Country: Denmark
Funding Organisation: French National Research Agency (ANR)
The Ministry of Food, Agriculture and Fisheries of Denmark
The Research Council of Norway
Federal Ministry of Food Agriculture and Consumer Protection (BMELV)
Animal Group: Fish
Pathogen: Herpesviruses
Viral hemorrhagic septicemia virus (VHSV)
Disease: Viral haemorrhagic septicaemia (VHS)
Infectious hematopoietic necrosis virus (IHNV)
Koi herpes virus (KHV) disease
Category: Epidemiology, Risk and Decision Support > Development, refinement, and evaluation of control strategies
Epidemiology, Risk and Decision Support > Generic/Fundamental epidemiology and modelling
Infection, immunity and biotechnology > Diagnostic test development, including microarray
Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Host-Pathogen interactions (including immunomodulation and immune evasion)
Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Molecular epidemiology
Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Virology
Infection, immunity and biotechnology > Generic capacity > Micro-organism collections
Research Organisation: National Veterinary Institute (DTU Vet)
FLI - Friedrich Loeffler Institute
National Veterinary Institute of Norway
French Agency for Food, Environmental and Occupational Health & Safety (ANSES)
French Research Institute for Exploitation of the Sea (IFREMER)
Institut de recherche pour le développement (IRD)
Norwegian Computing Center
Number of Research Staff (FTE):  
Principal Investigator (PI): Dr Edgar Brun, Norwegian Vetinerary Institute
Cost (Euros): 1990198
End Date (dd/mm/yyyy): 31-03-2015
Duration (months): 36
Project objectives and deliverables with estimated delivery dates for each deliverable (if possible): This project will i)generate and use spatio-temporal epidemiological data, phylogeographic data and
gene expression data for important host-viral pathogen systems to identify important factors affecting
the spread of diseases in aquaculture, and ii)integrate these in scenario simulation models to assess
effects of various control strategies for selected host-pathogen systems. The purpose of the project is to increase knowledge on transmission, prevention and control of viral diseases in aquaculture and
develop a generic approach to viral disease control by using information on epidemiological and
physiogenetical attributes from several important aquatic animal viruses.
The specific objectives are: 1)Collection of isolates of specific important aquatic animal viruses and their respective epidemiological data (from as wide host ranges, broad geographic distributions and variable pathogenicities as possible), 2)Characterisation of the isolates by phylogenetic and expression analyses and 3)Constructing scenario simulation models to assess effects of different control strategies.
The project partners cover different fields of expertise and will contribute accordingly.
NVI (NO) is the consortium coordinator of the project. NVI will be responsible for collecting surveillance data covering the incidence of viral infections in cultured populations in space and time and investigate the efficacy of disease intervention strategies.
DTU-VET (DK) will primarily undertake research on VHSV and perch rhabdoviruses and include its
large international strain collections for the project. DTU-Vet will expand the database with the virus isolates included in the studies and create new sub databases for OsHV-1 and SAV isolates.
ANSES (FR) has a large number of fish rhabdoviruses and various genotypes of nodaviruses, and will
participate in the molecular characterization of yet uncharacterized or only partially characterized
IFREMER (FR) has a collection of more than 100 samples infected with mollusc herpes-viruses, which will be used to investigate the genetic virus diversity. Bioinformatics will be applied to investigate the linkage between genomic features and virus properties.
IRD (FR) has an extensive collection of KHV-isolates, which will be genotyped and included in the
modelling methods. Furthermore, IRD will use own and other partner sequences to build DNA
microarrays for expression studies.
FLI (DE) will contribute with a large collection of IHNV, VHSV and KHV isolates. FLI will do comparative studies with regard to the origin, relationship and classification of the isolates. Additionally, FLI will work closely together with IRD in building microarrays.
NR (NO) will incorporate data generated from the other partners into models that can exploit both
traditional epidemiological data and genetic information on the disease agents, to simulate various
disease spread intervention scenarios.
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