Research Project Database
Code: EMIDA6
Title: CombatColibacillosis - Combatting colibacillosis - a genomics based approach.
Country: Italy
France
Israel
Germany
Funding Organisation: French National Research Agency (ANR)
Kimron Veterinary Institute (IVSAH)
Federal Ministry of Education and Research (BMBF, Germany)
Israeli Ministry of Agriculture and Rural Development
Italian Ministry of Health Department for Veterinary Public Health, Nutrition and Food Safety
Animal Group: Chickens
Turkeys
Pathogen: Escherichia coli
Disease: Colibacillosis
Category: Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Bacteriology
Infection, immunity and biotechnology > Fundamental/basic and Applied studies, including molecular, cellular, pathogen population dynamics and ecology > Host-Pathogen interactions (including immunomodulation and immune evasion)
Research Organisation: Novartis Animal Vaccines Ltd
Tel Aviv University
University of Würzburg
Ecole Nationale Vétérinaire de Toulouse and Faculté de médecine de Toulouse-Purpan
Number of Research Staff (FTE):  
Principal Investigator (PI): Ulrich Dobrindt, University of Würzburg
Cost (Euros): 936199
End Date (dd/mm/yyyy): 31-12-2013
Duration (months): 36
Link:  
Project objectives and deliverables with estimated delivery dates for each deliverable (if possible): Avian pathogenic Escherichia coli (APEC) cause extraintestinal diseases in birds known as colibacillosis which are costly for the poultry industry as they significantly reduce production. Although the most logical approach to control colibacillosis is through vaccination typical inactivated vaccines have only provided partial protection against homologous challenge. Specific virulence factors may provide a vaccine target capable of protection to heterologous challenge. For this purpose it is important to identify APEC factors involved in disease and in host recognition and to understand on the molecular level the interplay between APEC and eukaryotic cells resulting in establishment of an infection. This project focuses on the characterization of the molecular basis of APEC infection of poultry by proposing a global strategy to analyze the factors and traits involved in APEC pathogenesis. The overall scientific objective of this transnational collaborative project is to apply genomic approaches to exploit genomic data of APEC for the improvement of preventive and therapeutic strategies as well as of strain typing and risk assessment. The expected achievements of this project are to improve current strategies to combat APEC infection. The results obtained could thus be translated into new vaccine or drug targets and therapeutic approaches.
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