Research Project Database
Code: EMIDA11
Title: HealthyGut – Multi-focal strategies to improve gut health and reduce enteritis in poultry and pigs.
Country: United Kingdom
Czech Republic
Funding Organisation: Biotechnology and Biological Science Research Council (BBSRC)
Department for the Environment, Food and Rural Affairs (Defra)
French National Research Agency (ANR)
Federal Ministry of Education and Research (BMBF, Germany)
Czech Ministry of Agriculture
Ministero delle Politiche Agricole Alimentari e Forestali (MiPAAF)
Animal Group: Chickens
Pathogen: Mycobacterium spp.
Salmonella spp.
Eimeria spp.
Disease: Enteritis
Category: Epidemiology, Risk and Decision Support > Development, refinement, and evaluation of control strategies
Research Organisation: University of Nottingham
Istituto Superiore di Sanita
INRA - Institut National de la Recherche Agronomique
FLI - Friedrich Loeffler Institute
Lohmann Animal Health GmbH & Co
China Agricultural University (CAU)
Microbial Developments Ltd
Number of Research Staff (FTE):  
Principal Investigator (PI): Prof. P. A. Barrow, University of Nottingham
Cost (Euros): 2590764
End Date (dd/mm/yyyy): 31-12-2013
Duration (months): 36
Project objectives and deliverables with estimated delivery dates for each deliverable (if possible): The HealthyGut consortium will analyse
(i).changes in the gut flora at periods of increased susceptibility, in weaned pig, newly-hatched chickens and hens at onset of lay. From this we will develop bespoke flora preparations for use with laying hens and weaned pigs.
(ii).the basis of the rapid, generic innate immunity induced by live, Salmonella- and Mycobacterium-based bacterial vaccines and by the live Eimeria vaccine Paracox and their application to reduce susceptibility to enteric pathogens in pigs and poultry.
combining approaches (i) and (ii) in pigs and poultry.
The expected outcomes of HealthyGut will be;
Information on the changes that take place in the flora at periods of heightened susceptibility to enteric infection
Protective flora preparations for use with laying hens and weaned pigs
Information on the basis of the rapid, generic protection induced by live, bacterial vaccines and by the Eimeria vaccine Paracox.
Candidate live, attenuated generic Salmonella and Mycobacterial vaccines which will be available for use either prophylactically or therapeutically against enteric and other pathogens
Demonstration of the effectiveness of bespoke flora preparations and live vaccines singly and in combination in laying hens and weaned pigs.
Exploitation will be via the three commercial Partners, Partners 6 and 9 who have international reputations in live vaccines and Partner 8 with a similar reputation in gut flora preparations.
The consortium and proposed project fulfils the aims of the EMIDA initiative by:
Establishing a highly effective consortium with a long record of collaboration and a proven history of timely delivery.
Addressing several of the issues within Topic 3 (Major infectious diseases affecting production), namely developing methods which minimise reliance on the use of antimicrobials, developing methods of immunological intervention through vaccine utilisation and
reducing the impact of enteric disease on animal welfare and production costs.
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