Research Project Database
Code: 1.18.09
Title: Analysis of the bovine mammary gland resistome during herd sanitation of Staphylococcus aureus GTB
Country: Switzerland
Funding Organisation: Federal Food Safety and Veterinary Office FSVO
Animal Group:  
Research Organisation:  
Number of Research Staff (FTE):  
Principal Investigator (PI):  
Cost (Euros): 178464
End Date (dd/mm/yyyy): 31-03-2021
Duration (months): 36
Project objectives and deliverables with estimated delivery dates for each deliverable (if possible): Staphylococcus aureus genotype B (Staph. aureus GTB) causes contagious mastitis in cows associated with high costs and usage of antibiotics (AB). As a consequence, Swiss federal offices together with the authority and the dairy farmers of canton Tessin will sanitize GTB-positive herds during the next years. The aim of this proposal is, therefore, to monitor the changes of the udder resistome during this process. To do so, aseptic milk samples will be repeatedly collected from cows of GTB-positive and –negative herds characterized by former use of low, middle, and high amounts of AB, respectively. Bacteria isolated from milk will be tested for the minimal inhibitory concentration mainly towards penicillins and aminoglycosides. The genomes will be sequenced and evaluated for the presence and changes within the antimicrobial resistance (AMR) genes.
The project aims to assess the dynamics of AB resistance during GTB sanitation and to evaluate genetic trends that may end up in AMR. Observing these features within the udder resistome is key to maintaining the efficacy of AB.
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