Research Project Database
Code: 119381
1: 119381
Title: Investigation of the genetic diversity of the Hungarian PRRSV strains and the effect of RdRp on their evolution
2: Investigation of the genetic diversity of the Hungarian PRRSV strains and the effect of RdRp on their evolution
Country: Hungary
3: Hungary
Funding Organisation: National Research, Development and Innovation Office
4: National Research, Development and Innovation Office
Animal Group: Pigs
5: Pigs
Pathogen: Porcine reproductive and respiratory syndrome virus (PRRSV)
6: Porcine reproductive and respiratory syndrome virus (PRRSV)
Disease: Porcine reproductive and respiratory syndrome (PRRS)
7: Porcine reproductive and respiratory syndrome (PRRS)
Category: Disease pathogenesis, including pathogen biology, evolution and resistance
8: Disease pathogenesis, including pathogen biology, evolution and resistance
9: 79
Research Organisation: Institute for Veterinary Medical Research (Centre for Agricultural Research)
10: Institute for Veterinary Medical Research (Centre for Agricultural Research)
Number of Research Staff (FTE): 8
11: 8
Principal Investigator (PI): Zoltán Tádori
12: Zoltán Tádori
Cost (Euros): 98351
13: 98351
End Date (dd/mm/yyyy): 30-09-2020
14: 1601420400
Duration (months): 48
15: 48
Link: http://aoti.agrar.mta.hu/en/projects_NKFI_K119381
16: http://aoti.agrar.mta.hu/en/projects_NKFI_K119381
Project objectives and deliverables with estimated delivery dates for each deliverable (if possible): Estimated losses caused by Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in the USA and EU are at $664 million and €400 million per year respectively.
According to the latest survey, today more than 25% of the industrial pig farms (163 of the investigated 600) are infected with PRRSV in Hungary. To mitigate the high economic losses caused by the virus in 2010 a national eradication program was implemented with the goal to eliminate PRRSV until 2020. Successful completion of the PRRSV eradication plan is impeded by the lack of effective vaccine and detailed knowledge about the diversity and geographical distribution of the Hungarian PRRSV strains.

One of our main objectives is to survey the genetic diversity of the Hungarian PRRSV population to determine their geographical distribution and follow their spatio-temporal alterations during a four-year period.
The high mutability and the extreme antigenic variability make the protection against PRRSV particularly difficult. RNA dependent RNA polymerase (RdRp) of the virus plays a major role in the generation of the constant stream of viral variants that are most probably responsible not only for the wild variety of clinical manifestation of the PRRS but for increased pathogenicity and also for the inefficacy of vaccines against heterologous PRRSV infection. Presently scientific data is scarce about the fidelity of RdRps in different PRRSV genotypes and their effect on the mutation rate.

The second objective is to compare the mutation frequencies of viruses from different lineages and to evaluate the role of the RdRp in mutant generation and viral evolution by studying chimeric and field PRRSV strains.
17: Estimated losses caused by Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in the USA and EU are at $664 million and €400 million per year respectively.
According to the latest survey, today more than 25% of the industrial pig farms (163 of the investigated 600) are infected with PRRSV in Hungary. To mitigate the high economic losses caused by the virus in 2010 a national eradication program was implemented with the goal to eliminate PRRSV until 2020. Successful completion of the PRRSV eradication plan is impeded by the lack of effective vaccine and detailed knowledge about the diversity and geographical distribution of the Hungarian PRRSV strains.

One of our main objectives is to survey the genetic diversity of the Hungarian PRRSV population to determine their geographical distribution and follow their spatio-temporal alterations during a four-year period.
The high mutability and the extreme antigenic variability make the protection against PRRSV particularly difficult. RNA dependent RNA polymerase (RdRp) of the virus plays a major role in the generation of the constant stream of viral variants that are most probably responsible not only for the wild variety of clinical manifestation of the PRRS but for increased pathogenicity and also for the inefficacy of vaccines against heterologous PRRSV infection. Presently scientific data is scarce about the fidelity of RdRps in different PRRSV genotypes and their effect on the mutation rate.

The second objective is to compare the mutation frequencies of viruses from different lineages and to evaluate the role of the RdRp in mutant generation and viral evolution by studying chimeric and field PRRSV strains.
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